Products

BAF312 (Siponimod) is a potent sphingosine-1 receptor (S1P-R) modulator selectively targeting S1P1 and

S1P5 receptors [1]. BAF312 reduces inflammation by sequestering lymphocytes in lymphoid tissues [2].

BAF312 also binds its receptors on neurons, astrocytes and oligodendrocytes and present neuroprotective

effects [3]. Siponimod showed neuroprotective effects in the CNS of encephalomyelitis mice and organotypic

cultures. is currently under investigation in a clinical trial in secondary progressive multiple sclerosis patients

[4].

Chemical Formula:

C₂₉H₃₅F₃N₂O₃

CAS No.:

1230487-00-9

Molecular Weight:

516.6

Purity:

> 98%

Appearance:

White

Chemical Name:

(E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylic acid

Solubility:

Up to 200 mM in DMSO

Synonyms:

Siponimod

Storage:

For longer shelf life, store solid powder or DMSO solution at -20^oC desiccated.

References