Products

ABBV-744 is a selective bromodomain and extra-terminal (BET) inhibitor that preferentially bind to the 2nd

bromodomains (BD) than the 1st BD pf BET family proteins (i.e., BRD2. BRD3. BRD4) [1]. This selective

targeting of BD2 subsets of the BET bromodomain abolished the broad antiproliferative activities for previous

generation pan BET inhibitors, and only display antiproliferative activities in a limited number of cancer cell

lines, including acute myeloid leukaemia and prostate cancer that expressed the full-length androgen

receptor (AR) [2]. Improved tolerability is expected due to less impact on global transcription [3].

Chemical Formula:

C₂₈H₃₀FN₃O₄

CAS No.:

2138861-99-9

Molecular Weight:

491.55

Purity:

> 98%

Appearance:

Grey

Chemical Name:

N-ethyl-4-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide

Solubility:

Up to 200 mM in DMSO

Synonyms:

ABBV 744, ABBV744

Storage:

For longer shelf life, store solid powder or DMSO solution at -20^oC desiccated.

References

Catalog No.

Product Name

Size

C2874

ABBV-744

2mg, 10mg & 50mg