Products

PD168393 is a first generation quinazolin amine irreversible EGFR inhibitors that alkylates Cys-773 within the

ATP binding pocket [1]. While this compound did not progress into clinical application due to limited effect on

EGFR mutant T790M, numerous EGFR research used this as a reference compound to explore new

combinatory treatment strategies, evaluate application of EGFR inhibitors in new in vitro and in vivo cancer

model systems, and compare mechanisms of action for new generations of EGFR inhibitors [2,3].

Chemical Formula:

C₁₇H₁₃BrN₄O

CAS No.:

194423-15-9

Molecular Weight:

369.22

Purity:

> 98%

Appearance:

Orange

Chemical Name:

N-(4-((3-bromophenyl)amino)quinazolin-6-yl)acrylamide

Solubility:

Up to 200 mM in DMSO

Synonyms:

PD168393

Storage:

For longer shelf life, store solid powder or DMSO solution at -20^oC desiccated.

References