Products

Pronanosomes, for ready-to-use to obtain nanovesicles with different characteristics

Standard & Cationic Pronanosomes

Pronanosome은 ready-to-use의 liposome, niosome 및 thermosensitive nanovesicles 준비를 위한 제품입니다.

1 회분 시약이 들어있는 유리병에 목적물질을 첨가하는 등 간단한 조작으로 목적물질을 내포한 liposome 및

niosome 등을 만들 수가 있습니다.

Pronanosomes are ready-to-use formulations to obtain nanovesicles, in a fast and easy way, able to

encapsulate a wide range of compounds such as hydrophilic and lipophilic molecules, peptides & proteins,

etc.

The main advantages of Pronanosomes are,

– Easy and fast nanoencapsulation of a wide range of compounds

– Easy size control

– Great stability

Standard Pronanosome

Standard Pronanosomes are formulations to obtain, in a fast and easy way, nanovesicles able to

encapsulate a wide variety of compounds. In addition, standard Pronanosomes can be used in different

applications such as drug delivery, foods and cosmetics.

* Pronanosome Lipo-N

* Pronanosome Nio-N

Nanovesicles formed from Pronanosomes are able to encapsulate a wide variety of compounds as

hydrophlic or lipophilic molecules, peptides, enzymes and proteins, among others. In addition, nanovesicles

have a great stability,  an easily controllable size and great entrapment efficiencies. A complete protocol of

use is attached with the product, if you still have questions or need more information about theproduct, we

help you. Nanovex Biotechnologies offers free advice for all products.

Nanovesicles obtained from Pronanosomes have multiple applications such as,

• Drug delivery and targeting

• Delivery of peptide drugs and proteins

• Studying Inmune response

• (Trans)dermal drug delivery systems

• Nutraceuticals and food applications

• Cosmetics

• Others

Pronanosome Nio-Nformulation is designed to obtain non-ionic surfactant vesicles (niosomes) which are

known for their stability and versatility and can be employed in multiple applications as: drug delivery and

targeting, delivery of peptides, drug and proteins, studying of inmune response, dermal or transdermal

delivery, cosmetics, functional foods & nutraceuticals, etc.

Niosomes have advantages such as,

• They are osmotically active and stable.

• They increase the stability of the entrapped drug

• Handling and storage of niosomes do not require any special conditions

• Can increase the oral bioavailability of drugs

• Can enhance the skin penetration of drugs

• They can be used for oral, parenteral as well topical.

• Niosomes are biodegradable, biocompatible, and non-immunogenic.

• Improve the therapeutic performance of the drug by protecting it from the biological environment.

• The niosomal dispersions in an aqueous phase can be emulsified in a non-aqueous phase to control the

   release rate of the drug and administer normal vesicles in external non-aqueous phase.

Niosome characteristics depending on the preparation method from Pronanosome Nio-N

And Pronanosome Lipo-Nformulation is designed to obtain liposomes from natural phospholipids.

Liposomes are the most common nanovesicles and can be used in several applications as: drug delivery

and targeting, delivery of peptides, drug and proteins, studying of inmune response, dermal or transdermal

delivery, cosmetics, functional foods & nutraceuticals, etc.

Liposomes have advantages such as,

• They are osmotically active and stable.

• They increase the stability of the entrapped drug

• Good solubilisation power

• Increased stability due to the surface electric charge

• Can increase the oral bioavailability of drugs

• Can enhance the skin penetration of drugs

• They can be used for oral, parenteral as well topical.

• Niosomes are biodegradable, biocompatible, and non-immunogenic.

• Improve the therapeutic performance of the drug by protecting it from the biological environment.

• Exhibit good colloidal, chemical and biological stability

Intracellular/in vitro(cationic) Pronanosomes

Intracellular/in vitro Pronanosomes are formulations to obtain, in a fast and easy way, nanovesicles

positively charged which are endocyted by cells to achieve intracellular delivery. This Pronanosomes can be

ordered with other characteristics such as PEGylated (for Intracellular in vivo assays), fluorescent or

bioconjugable.

* Pronanosome Lipo-cat

* Pronanosome Nio-cat

Pronanosome Nio-Cat formulation is designed to obtain niosomes positively charged (cationic niosomes).

Cationic nanovesicles can be endocyted by cells to achieve intracellular delivery. Cationic niosomes can be

also employed in other applications as: drug delivery and targeting, delivery of peptides, drug and proteins,

studying of inmune response, dermal or transdermal delivery, cosmetics, functional foods & nutraceuticals,

etc.

Cationic niosomes have advantages such as,

• They are osmotically active and stable.

• They increase the stability of the entrapped drug

• Handling and storage of niosomes do not require any special conditions

• Increased stability due to the surface electric charge

• Can increase the oral bioavailability of drugs

• Can enhance the skin penetration of drugs

• They can be used for oral, parenteral as well topical.

• Niosomes are biodegradable, biocompatible, and non-immunogenic.

• Can be easily endocytosed by cells

• Improve the therapeutic performance of the drug by protecting it from the biological environment.

• The niosomal dispersions in an aqueous phase can be emulsified in a non-aqueous phase to control the

   release rate of the drug and administer normal vesicles in external non-aqueous phase.

Pronanosome Lipo-Cat formulation is designed to obtain liposomes positively charged (cationic liposomes).

Cationic nanovesicles can be endocyted by cells to achieve intracellular delivery. Besides,  liposomes can

be used in several applications as: drug delivery and targeting, delivery of peptides, drug and proteins,

studying of inmune response, dermal or transdermal delivery, cosmetics, functional foods & nutraceuticals,

etc.

Cationic liposomes have advantages such as,

• They are osmotically active and stable.

• They increase the stability of the entrapped drug

• Good solubilisation power

• Increased stability due to the surface electric charge

• Can increase the oral bioavailability of drugs

• Can enhance the skin penetration of drugs

• They can be used for oral, parenteral as well topical.

• Liposomes are biodegradable, biocompatible, and non-immunogenic.

• Improve the therapeutic performance of the drug by protecting it from the biological environment.

• Easily endocyted by cells – Intracellular delivery

• Exhibit good colloidal, chemical and biological stability

Other Pronanosomes

Bioconjugable pronanosomes (Bioconjugable-COOH & Bioconjugable-Maleimide)

Bioconjugable nanovesicles can be conjugated with several biocompounds such as proteins, enzymes and

antibodies among others. Pronanosome bioconjugable series have several applications, among which the

following are of note,

• Active targeting of drug (drug/protein/peptide, etc.) loaded liposome

• Inmunochemical

• Diagnostics

Controlled delivery Pronanosomes (Thermo/Thermosensitive)

Pronanosome Thermo is a ready-to-use formulation specially designed to obtain thermosensitive

nanovesicles, which are able to release their content above  40-42 ℃ or pH values lower than 5.5.

Pronanosome THERMO can be used in several applications when a controlled delivery of the encapsulated

compound with temperature is needed. The main application of Pronanome THERMO is drug delivery,

although the product has other applicatios such as,

Studying of inmune response, dermal or transdermal delivery, cosmetics, functional foods, smart labelling &

nutraceuticals, etc.

Fluorescent Pronanosomes (Pronasome - GF)

Fluorescent nanovesicles are very useful to in vivo/in vitro/in situ/ex vivo nanovesicle detection.

Pronanosome green fluorescence series allow to obtain fluorescently labelled nanovesicles (Green

fluorescence) in a fast and easy way.

In vivo Pronanosomes (Pronanosome PEGylated/Stealth)

Nanovesicles containing PEG on the surface has been shown to extend blood-circulation time while

reducing mononuclear phagocyte system uptake (stealh nanovesicles). PEGylated nanovesicles have high

stability due the sterical repulsion.  The presence of PEG on the surface of the nanovesicles has been

shown to extend blood-circulation time while reducing mononuclear phagocyte system uptake (stealth

nanovesicles). This technology has resulted in a large number of nanovesicle formulations encapsulating

active molecules, with high target efficiency and activity. Speciallysuited to “in vivo” assays.

 How to choose the appropriate nanovesicle