Products

GsMTx4, Selective blocker of mechanosensitive ion channels

Blockers of mechanosensitive (stretch-activated) ion channels

 

 

GsMTx4 (GsMTx-4, M-theraphotoxin-Gr1a) has been isolated from the venom of the spider Grammostola

rosea. This cationic hydrophobic polypeptide blocks selectively the gating of cation selective channels and

mechanosensitive ion channels such as TROC1 or TRPC6 , without having any effect on whole-cell voltage-

sensitive currents. This toxin acts by perturbing the interface between the channel and the lipid bilayer

without necessarily being in physical contact with the channel. GsMtx4 also demonstrated to active

TRPA1 channel at 1µM concentration and to inhibit Piezo1 currents.

 

Details

AA sequence:		AA sequence: Gly-Cys2-Leu-Glu-Phe-Trp-Trp-Lys-Cys9-Asn-Pro-Asn-Asp- Asp-Lys-Cys16-Cys17-Arg-Pro-Lys-Leu-Lys-Cys23-Ser-Lys-Leu-Phe-Lys- Leu-Cys30-Asn-Phe-Ser-Phe-NH2
Disulfide bonds:		Cys2-Cys17, Cys9-Cys23 and Cys16-Cys30
Length (aa):		34
Formula:		C185H273N49O45S6
Molecular Weight:		4095.25. Da
Appearance:		White lyophilized solid
Solubility:		Water and saline buffer
Source:		Synthetic
Purity rate		> 97 %

 

 

Reference

1. Anderson M, et al. (2013) Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked

    by membrane stretch or diacylglycerol. Am J Physiol Cell Physiol. PubMed link