Toll-like Receptor Ligands
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Toll-like Receptor Ligands
Product Name: Gardiquimod – TLR7 Ligand
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Selective ligand for human or mouse Toll-like receptor 7 (TLR7). Induces the activation of NF-κB in HEK 293 cells expressing TLR7. At high concentrations (3µg/ml) slightly activates TLR8. More active than Imiquimod (Cat# CD0115). |
Details
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Chemical Formula: |
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C17H23N5O |
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CAS No.: |
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1020412-43-4 |
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Molecular weight: |
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313.4. |
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Purity: |
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99% by HPLC |
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Appearance: |
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White solid |
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Chemical name: |
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1-(4-Amino-2-ethylaminomethylimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol |
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Solubility: |
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DMSO (>40 mg/mL), dioxane (7 mg/mL), methanol (>40 mg/mL) |
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Storage: |
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Protect from light. Packaged under inert gas |
References
1. Velasquez, L. S. et al. Clin Vaccine Immunol. 2010, 17, 1850;
2. Du, J. et al. Vaccine. et al. 2010, 28, 6273;
3. Ma, F. et al. Cell Mol Immunol. 2010, 7, 381;
4. Gill, M. A. et al. J Immunol. 2010, 184, 5999;
5. Ma, Y. et al. Immunology. 2010, 130, 374;
6. Forward, N. A. et al. J Leukoc Biol. 2010, 87, 117;
7. Baldwin, S. L. et al. Vaccine. 2009, 27, 3063;
8. Zhu, J. et al. Mol Immunol. 2009, 46, 978;
9. Parker, L. C. et al. J Immunol. 2008, 181, 5606;
Product Name: Loxoribine (RWJ 21757) – TLR7 Ligand
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Selective ligand for Toll-like receptor 7 (TLR7) via IFN. Activates natural killer cells and primes cytolytic precursor cells for activation by IL-2 |
Details
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Chemical Formula: |
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C13H17N5O6 |
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CAS No.: |
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121288-39-9 |
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Molecular weight: |
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339.3. |
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Purity: |
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98% by HPLC |
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Appearance: |
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White solid |
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Chemical name: |
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7-Allyl-8-oxoguanosine (7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine) |
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Solubility: |
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(30 mg/mL), water (10 mg/mL). |
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Storage: |
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Protect from light. Packaged under inert gas |
References
1. Bekeredjian-Ding, I. B. et al. J. Immunol. 2005, 174, 4043;
2. Lee, J. et al. PNAS 2003, 100, 6646 ;
3. Pope, B. L. et al. Cell. Immunol. 1995, 162, 333 ;
4. Goodman, M. G. et al. Blood 1994, 84, 3457 ;
5. Schindler, U. Mol. Cell. Biol. 1994, 14, 5820 ;
6. Pope, B. L. et al. J. Immunol. 1993, 151, 3007.
Product Name: R-848 (Resiquimod, S 28463) – TLR7 and TLR8 Ligand
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R-848 is a selective ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. Potent antitumor and antiviral compound. Stimulates antibody secretion, cytokine production, protection from apoptosis and CD80 upregulation. |
Details
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Chemical Formula: |
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C17H22N4O2 |
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CAS No.: |
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144875-48-9 |
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Molecular weight: |
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314.4 |
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Purity: |
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99% by HPLC |
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Appearance: |
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white solid |
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Chemical name: |
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4-Amino-2-(ethoxymethyl)-a,a-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol |
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Solubility: |
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DMSO |
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Storage: |
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Protect from light. Packaged under inert gas |
References
2. Grela, F. et al.; J. Immunol. 2011, 186, 284;
3. Pham Van, L. et al.; Eur. J. Immunol. 2011, 41, 1992;
4. Jensen, S. S. & Gad, M. J. Inflamm. 2010, 7, 37;
5. Butchar, J. P. et al. Clin. Cancer Res. 2010, 16, 2065;
6. Aumeunier, A. et al. PLOS ONE 2010, 5, e11484;
7. Xirakia, C. et al. Am. J. Respir. Crit. Care Med. 2010, 181, 1207;
8. Peters, A. L. et al. Blood 2008, 112, 1863;
9. McCluskie, M. J. et al. Antiviral Res. 2006, 69, 77;
10. Caron, G. et al. J. Immunol. 2005, 175, 1551;
11. Weeratna, R. D. et al. Vaccine 2005, 23, 5263;
12. Wu, J. et al. Antiviral Res. 2004, 64, 79;
13. Jurk, M. et al. Nat. Immunol. 2002, 3, 499;
14. Hemmi, H. et al. Nat. Immunol. 2002, 3, 196;
15. Bishop, G. A. et al. Cell. Immunol. 2001, 208, 9.
Ordering informations
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Catalog No. |
Product Name |
Size |
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CD0204 |
Gardiquimod – TLR7 Ligand |
10mg, 25mg, 50mg, 100mg, 250mg & 1mg |
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CD0198 |
Loxoribine (RWJ 21757) – TLR7 Ligand |
10mg, 25mg, 50mg, 100mg, 250mg & 1g |
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CD0271 |
R-848 (Resiquimod, S 28463) – TLR7 and TLR8 Ligand |
1mg, 5mg, 10mg, 25mg, 50mg ,100mg, 250mg & 1g |
▣ 관련 페이지 ; Chemdea
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