ATM ligands, KU-55933 - ATM Kinase Inhibitor
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ATM ligands
Product Name: KU-55933 - ATM Kinase Inhibitor
A cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase
(IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3 , 16.6 µM for DNA-
PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other
kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following
ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-
damaging agents.
Details
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Chemical Formula:
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C21H17NO3S2
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CAS No.:
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587871-26-9
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Molecular weight:
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395.5
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Purity:
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99% by HPLC
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Appearance:
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White solid
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Chemical name:
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2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one
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Solubility:
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DMSO (4mg/mL)
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Storage:
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Protect from light. Packaged under inert gas
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References
Ordering information
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Catalog No.
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Product Name
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Size
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CD0191
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KU-55933 - ATM Kinase Inhibitor
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1mg, 5mg, 10mg, 25mg,
50mg, 100mg, 200mg & 1g
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