Purity 99%, ROCK Inhibitor Y-27632
본문
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ROCK Inhibitor (Y-27632) (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide Dihydrochloride
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinase (Ki= 140 nM for p160ROCK (ROCK-I). Also inhibitsROCK-II with almost equal potency. Inhibition is achieved by competing with ATP for binding to the catalytic site. Exhibits 10- to 50-fold lower affinity for PKCεthan p160ROCK. Does not affect the activity of p21-activated protein kinase(PAK) even at high concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contractions (IC50 = 700 nM for phenylephrine-inducedcontractions in aortic strips). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hEScells without affecting their pluripotency. |
Details
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Chemical Formula: |
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C14H21N3O·2HCl·H2O |
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CAS No.: |
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146986-50-7 |
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Molecular weight: |
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338.3. |
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Purity: |
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99% by HPLC |
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Appearance: |
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white solid |
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Chemical name:
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(1E,4S,4aR,5R,6aS,7S,9aR)-5-(Acetyloxy)-1-[[[3-(dimethylamino)propyl] methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4- (methoxymethyl)-4a,6a-dimethylcyclopenta[5,6]na-phtho[1,2-c]pyran-2,10(1H,4H) -dione |
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Solubility: |
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water (100 mg/mL) |
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Storage: |
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Protect from light. Packaged under inert gas |
References
1. Watanabe, K. et al. Nature Biotech. 2007, 25, 681;
2. Chitaley, K. et al. Nat. Med. 2001, 7, 119;
3. Davies, S. P. et al. Biochem. J. 2000, 351, 95;
4. Narumiya, S. et al. Methods Enzymol. 2000, 325, 273;
5. Hirose, M. et al. J. Cell Biol. 1998, 141, 1625;
Ordering information
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Catalog No. |
Product Name |
Size |
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CD0141 |
ROCK Inhibitor (Y-27632) |
1mg, 5mg, 10mg, 25mg, 50mg ,100mg, 250mg & 1g |
▣ 관련 페이지 ; Chemdea
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