Products

ONO-7475 is a potent inhibitor of Anexelekto(Axl)/MER tyrosine kinase with IC50 at nM range for both AXL

and MER.  AXL has been implicated in diverse tumor-promoting processes such as proliferation, migration,

invasion, survival, and apoptosis, and therefore considered a promising druggable target to overcome drug

resistance for acute myeloid leukemia, pancreatic cancer [2], lung cancer [3], as well as breast cancer [3].

ONO-7475 sensitizes and suppresses the emergence of tolerant cells to the initial EGFR-TKIs, osimertinib or

dacomitinib, in AXL-overexpressing EGFR-mutated NSCLC cells, suggesting that ONO-7475 and osimertinib

is a highly potent combination for initial treatment of NSCLC.

Chemical Formula:

C₃₂H₂₆N₄O₆

CAS No.:

1646839-59-9

Molecular Weight:

562.57

Purity:

> 98%

Appearance:

Off-White

Chemical Name:

N-(5-((6,7-dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide

Solubility:

Up to 150 mM in DMSO

Synonyms:

ONO 7475, ONO7475

Storage:

For longer shelf life, store solid powder or DMSO solution at -20^oC desiccated.

References