PIKfyve Inhibitor
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PIKfyve Inhibitor
Product Name: YM201636 – PIKfyve Inhibitor
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A cell-permeable pyridofuropyrimidine compound that selectively inhibits mammalian type III PtdInsP kinase (IC50 = 33 nM and >5 µM using murine PIKfyve and yeast Fab1, respectively), while exhibiting much reduced activity against p110a (IC50 = 3.3 µM) and little activity against type IIg PtdInsP kinase even at concentrations as high as 10 µM. Shown to block serum-induced PtdIns(3,5)P2 production in NIH3T3 cells (80% inhibition at 800 nM) and disrupt cellular endosomal transport in a reversible manner. |
Details
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Chemical Formula: |
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C25H21N7O3 |
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CAS No.: |
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371942-69-7 |
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Molecular weight: |
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467.5 |
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Purity: |
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98% by HPLC |
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Appearance: |
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White solid |
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Chemical name: |
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6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide |
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Solubility: |
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DMSO (1 mg/mL) Enhanced solubility can be achieved by the addition of a small drop of TFA |
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Storage: |
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Protect from light. Packaged under inert gas |
Reference
1. Jefferies, H.B.J., et al. EMBO Reports 2008, 9, 164.
Ordering information
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Catalog No. |
Product Name |
Size |
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CD0181 |
YM201636 – PIKfyve Inhibitor |
1mg, 5mg, 10mg, 25mg, 50mg & 100mg |
▣ 관련 페이지 ; Chemdea
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