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작성일 : 14-04-05
[Chemdea] Toll-like Receptor Ligands
Gardiquimod / Loxoribine (RWJ 21757) / R-848 (Resiquimod, S 28463) - TLR7 and TLR8 Ligand


Toll-like Receptor Ligands



Product Name: Gardiquimod – TLR7 Ligand


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Selective ligand for human or mouse Toll-like receptor 7 (TLR7). Induces the activation of NF-κB in HEK 293 cells

expressing TLR7. At high concentrations (3µg/ml) slightly activates TLR8. More active than Imiquimod (Cat# CD0115).


Details

Chemical Formula:

 

C17H23N5O

CAS No.:

 

1020412-43-4

Molecular weight:

 

313.4.

Purity:

99% by HPLC

Appearance:

 

White solid

Chemical name:

 

1-(4-Amino-2-ethylaminomethylimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol

Solubility:

 

DMSO (>40 mg/mL), dioxane (7 mg/mL), methanol (>40 mg/mL)

Storage:

Protect from light. Packaged under inert gas


References

 


Product Name: Loxoribine (RWJ 21757) – TLR7 Ligand


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Selective ligand for Toll-like receptor 7 (TLR7) via IFN. Activates natural killer cells and primes cytolytic precursor cells

for activation by IL-2


Details

Chemical Formula:

 

C13H17N5O6

CAS No.:

 

121288-39-9

Molecular weight:

 

339.3.

Purity:

98% by HPLC

Appearance:

 

White solid

Chemical name:

 

7-Allyl-8-oxoguanosine (7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine)

Solubility:

 

(30 mg/mL), water (10 mg/mL).

Storage:

Protect from light. Packaged under inert gas


References


Product Name: R-848 (Resiquimod, S 28463) – TLR7 and TLR8 Ligand


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R-848 is a selective ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. Potent

antitumor and antiviral compound. Stimulates antibody secretion, cytokine production, protection from apoptosis and

CD80 upregulation.


Details

Chemical Formula:

 

C17H22N4O2

CAS No.:

 

144875-48-9

Molecular weight:

 

314.4

Purity:

99% by HPLC

Appearance:

 

white solid

Chemical name:

 

4-Amino-2-(ethoxymethyl)-a,a-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol

Solubility:

 

DMSO

Storage:

Protect from light. Packaged under inert gas


References

2. Grela, F. et al.; J. Immunol. 2011, 186, 284;

3. Pham Van, L. et al.; Eur. J. Immunol. 2011, 41, 1992;

4. Jensen, S. S. & Gad, M.  J. Inflamm. 2010, 7, 37;

5. Butchar, J. P. et al. Clin. Cancer Res. 2010, 16, 2065;

6. Aumeunier, A. et al. PLOS ONE 2010, 5, e11484;

7. Xirakia, C. et al. Am. J. Respir. Crit. Care Med. 2010, 181, 1207;

8. Peters, A. L. et al. Blood 2008, 112, 1863;

9. McCluskie, M. J. et al. Antiviral Res. 2006, 69, 77;

10. Caron, G. et al. J. Immunol. 2005, 175, 1551;

11. Weeratna, R. D. et al. Vaccine 2005, 23, 5263;

12. Wu, J. et al. Antiviral Res. 2004, 64, 79;

13. Jurk, M. et al. Nat. Immunol. 2002, 3, 499;

14. Hemmi, H. et al. Nat. Immunol. 2002, 3, 196;

15. Bishop, G. A. et al. Cell. Immunol. 2001, 208, 9.

 


Ordering informations

Catalog No.

Product Name

Size

CD0204

Gardiquimod – TLR7 Ligand

10mg, 25mg, 50mg, 100mg,

 250mg & 1mg

CD0198

Loxoribine (RWJ 21757) – TLR7 Ligand

10mg, 25mg, 50mg, 100mg,

250mg & 1g

CD0271

R-848 (Resiquimod, S 28463) – TLR7 and TLR8 Ligand

1mg, 5mg, 10mg, 25mg,

50mg ,100mg, 250mg & 1g


 

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