Product Name: NSC23766 Hydrochloride – Rac1 Inhibitor
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A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1.
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N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
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Protect from light. Packaged under inert gas
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References
1. Desire, L., et al. J. Biol. Chem. 2005, 280, 37516;
2. Gao, Y., et al. Proc. Natl. Acad. Sci. USA 2004, 101, 7618.
Ordering information
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Catalog No.
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Product Name
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Size
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CD0192
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NSC23766 Hydrochloride – Rac1 Inhibitor
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1mg, 5mg, 10mg, 25mg, 50mg,
100mg, 250mg, 500mg & 1g
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▣ 관련 페이지 ; Chemdea
작성일 : 14-04-05
