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작성일 : 14-04-05
[Chemdea] Rac Inhibitors
NSC23766 Hydrochloride


Rac Inhibitors

 


Product Name: NSC23766 Hydrochloride – Rac1 Inhibitor


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A cell-permeable pyrimidine compound that specifically and reversibly inhibits Rac1 GDP/GTP exchange activity by

interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and

Tiam1 (IC50 ~50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective

dose ~50 to 100 μM). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP

or PAK1.


Details

Chemical Formula:

 

C24H35N7*3HCl.

CAS No.:

 

1177865-17-6

Molecular weight:

 

530.96

Purity:

99% by HPLC

Appearance:

 

White solid

Chemical name:

 

N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride

Solubility:

 

water

Storage:

Protect from light. Packaged under inert gas


References

1. Desire, L., et al. J. Biol. Chem. 2005, 280, 37516;

2. Gao, Y., et al. Proc. Natl. Acad. Sci. USA 2004, 101, 7618.

   


Ordering information

Catalog No.

Product Name

Size

CD0192

NSC23766 Hydrochloride – Rac1 Inhibitor

1mg, 5mg, 10mg, 25mg, 50mg,

100mg, 250mg, 500mg & 1g


 

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