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작성일 : 14-03-07
[Chemdea] PIKfyve Inhibitor


PIKfyve Inhibitor


 

Product Name: YM201636 – PIKfyve Inhibitor


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A cell-permeable pyridofuropyrimidine compound that selectively inhibits mammalian type III PtdInsP kinase (IC50 =

33 nM and >5 µM using murine PIKfyve and yeast Fab1, respectively), while exhibiting much reduced activity against 

p110a (IC50 = 3.3 µM) and little activity against type IIg PtdInsP kinase even at concentrations as high as 10 µM. Shown

to block serum-induced PtdIns(3,5)P2 production in NIH3T3 cells (80% inhibition at 800 nM) and disrupt cellular

endosomal transport in a reversible manner.


Details


Chemical Formula:

 

C25H21N7O3

CAS No.:

 

371942-69-7

Molecular weight:

 

467.5

Purity:

98% by HPLC

Appearance:

 

White solid

Chemical name:

 

6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine  carboxamide

Solubility:

 

DMSO (1 mg/mL) Enhanced solubility can be achieved by the addition of a small drop of TFA

Storage:

Protect from light. Packaged under inert gas


Reference


1. Jefferies, H.B.J., et al. EMBO Reports 2008, 9, 164.


 

Ordering information

Catalog No.

Product Name

Size

CD0181

YM201636 – PIKfyve Inhibitor

1mg, 5mg, 10mg, 25mg,

50mg & 100mg

 


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