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작성일 : 14-01-20
[Lunginnov] Anti-mouse biotinylated Endocan / ESM-1 Ab (N-Ter) GGR222
 
Anti-mouse biotinylated Endocan / ESM-1 Ab (N-Ter) GGR222
 
 
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Anti-mouse endocan / ESM-1 biotinylated antibody GGR222 detects the N-terminus of mouse and rat endocan.
This antibody is recommended for ELISA.
 
 
Informations
  • Clone ;  GGR222
  • Epitope ; N-Ter
  • Format  ; 1 tube / 50 µg  
  • Application ; ELISA
  • Isotype ; IgG2a, K
 
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Endocan also known as endothelial cell-specific molecule (ESM-1) was originally discovered by Lassalle and colla-borators
in endothelial cells (Lassalle et al. 1996). Structurally, endocan is a dermatan sulfate proteoglycan of 50 kDa that is freely
circulating in blood (Bechard et al. 2001a; Sarrazin et al. 2010b). Endocan binds CD11a/CD18 integrin (also called LFA-1
for Leukocyte Function-associated Antigen-1) on human leukocytes inhibiting consequently its binding to ICAM-1 (Bechard
et al. 2001b). The expression of endocan / ESM-1 is upregulated by pro-inflammatory molecules such as tumor necrosis
factor alpha (TNFa), lipopolysaccharides (LPS) and also pro-angiogenic molecules such as vascular endothelial growth
factor (VEGF), fibroblast growth factor 2 (FGF-2) (Grigoriu et al. 2006; Sarrazin et al. 2006; Maurage et al. 2009 ; Leroy
et al. 2010 ; Sarrazin et al. 2010a). Endocan / ESM-1 binds via its dermatan sulfate chain to hepatocyte growth
factor/scatter factor (HGF/SF) (Bechard et al. 2001a ; Sarrazin et al. 2010a). Recently endocan / ESM-1 was identified
as a biomarker of tip cells (Strasser et al. 2010 ; Del Toro et al. 2010).  Elevated blood levels of endocan / ESM-1 has been
reported in patients with lung and kidney cancers as well as in patients with severe sepsis (Bechard et al. 2001b;
Scherpereel et al. 2003; Grigoriu et al. 2006; Scherpereel et al. 2006 ; Leroy et al. 2010). Endocan is a biomarker of
activated endothelium (Sarrazin et al. 2010b).
 
 
Main features
  • Monoclonal antibody (RAT)
  • Affinity purified
  • Detect the N-terminus of murine endocan
  • Storage at - 20 ° C
 
 
 
 
References
1. Bechard et al. (2000) J. Vasc. Res. 37:417-425 (Pubmed)
2. Depontieu et al. (2012) J Immunol Methods. 378:88-94 (Pubmed)
3. Grigoriu et al. (2006) Clin. Cancer Res. 12:4575-4582 (Pubmed)
4. Maurage et al. (2009) Exp. Neurol. 68:836-844 (Pubmed)
5. Leroy et al. (2010) Histopathology 56:180-187 (Pubmed)
6. Sarrazin et al. (2010a) J. Cancer. Sci. Ther. 2:47-52 (pdf)
7. Sarrazin et al. (2010b) Glycobiology 20:1380-1388 (Pubmed)
 
 
Ordering information
 
Catalog No.
Product Name
Size
LIA-0905BB
Anti-mouse biotinylated Endocan / ESM-1 Ab (N-Ter) GGR222
50 µg
 
 
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