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작성일 : 14-01-13
[Chemdea] mTOR Selective inhibitors (2)
WYE-23 – sub-nanomolar selective / WYE-28 – sub-nanomolar selective / WYE-354 – mTOR Inhibitor
 
mTOR selective inhibitors (2)
 
 
Product Name: WYE-23 – sub-nanomolar selective mTOR Inhibitor
   
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Novel potent and selective mTOR inhibitor. Inhibits mTOR kinase with IC50 = 0.45 nM and PI3 kinase (PI3K), with p110α
IC50 = 661 nM. It shows improved cellular potency LNCap IC50 = 42 nM as compared to WYE-354 (Cat # CD0270). 
WYE-23 microsomal stability T1/2 was shown to be > 30 min.
 
Details
Chemical Formula:
 
C26H32N8O4
CAS No.:
 
1062169-46-3
Molecular weight:
 
520.6
Purity:
99% by HPLC
Appearance:
 
White solid
Chemical name:
 
4-{6-[4-(3-Cyclopropyl-ureido)-phenyl]-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl}-
piperidine-1-carboxylic acid methyl ester
Solubility:
 
DMSO (11mg/mL)
Storage:
Protect from light. Packaged under inert gas
 
References
 
Product Name: WYE-28 – sub-nanomolar selective mTOR Inhibitor
 
   클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요
 
Novel potent and selective mTOR inhibitor. Inhibits mTOR kinase with IC50 = 0.08 nM and PI3 kinase (PI3K), with p110α
IC50 = 6 nM. It shows improved cellular potency LNCap IC50 < 1 nM as compared to WYE-354 (Cat # CD0270) and
WYE-23 (Cat # CD0275).
 
Details
Chemical Formula:
 
C30H34N8O5
CAS No.:
 
1062172-60-4
Molecular weight:
 
586.6
Purity:
99% by HPLC
Appearance:
 
White solid
Chemical name:
 
4-(6-{4-[3-(4-Hydroxymethyl-phenyl)-ureido]-phenyl}-4-morpholin-4-yl-pyrazolo[3,4-d]
pyrimidin-1-yl)-piperidine-1-carboxylic acid methyl ester
Solubility:
 
DMSO (66mg/mL)
Storage:
Protect from light. Packaged under inert gas
 
Reference
 
Product Name: WYE-354 – mTOR Inhibitor
 
  클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요
 
A cell-permeable pyrazolopyrimidine compound that acts as a potent and ATP competitive inhibitor of mTOR (IC50 =
4 nM). Active in LNCap cellular assay (IC50 = 355 nM). Selective against PI3K’s (p110a  IC50 = 1026 nM, p110b,  p110g,  
p110d > 6000 nM). Selective against other PIKK’s and other kinases. When injected into tumor-bearing nude mice, 
WYE-354 inhibited mTORC1 and mTORC2 and displayed robust antitumor activity in PTEN-null tumors.  
 
Details
Chemical Formula:
 
C24H29N7O5
CAS No.:
 
1062169-56-5
Molecular weight:
 
495.5
Purity:
99% by HPLC
Appearance:
 
White solid
Chemical name:
 
4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-
yl]-1piperidinecarboxylic acid methyl ester
Solubility:
 
DMSO (50mg/mL)
Storage:
Protect from light. Packaged under inert gas
 
References
 
Ordering informations
 
Catalog No.
Product Name
Size
CD0275
WYE-23 – sub-nanomolar selective mTOR Inhibitor
1 mg, 5 mg, 10 mg
& 25 mg
CD0276
WYE-28 – sub-nanomolar selective mTOR Inhibitor
1 mg, 5 mg, 10 mg
& 25 mg
CD0270
WYE-354 – mTOR Inhibitor
1 mg, 5 mg, 10 mg, 25 mg,
50 mg, 100 mg & 200 mg
 
 
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