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작성일 : 13-12-09
[Lunginnov] Dermatan sulfate chains from recomb. human Endocan
 
Dermatan sulfate chains from recombinant human Endocan
 
 
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Endocan / ESM-1 is a proteoglycan carrying a unique chain of glycosaminoglycan (dermatan sulfate also called chondroitin sulfate B) This chain of dermatan sulfate is responsible for instance, of the proangiogenic activity of Endocan / ESM-1.
 
 
Informations
  • Biomolecules  Endocan  
  • Application  Bioassay  
  • Format  10 µg  
  • Source  Human
 
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Endocan also known as endothelial cell-specific molecule (ESM-1) was originally discovered by Lassalle and colla-borators in endothelial cells (Lassalle et al. 1996). Structurally, endocan is a dermatan sulfate proteoglycan of 50 kDa that is freely
circulating in blood (Bechard et al. 2001a; Sarrazin et al. 2010b). Endocan binds CD11a/CD18 integrin (also called LFA-1
for Leukocyte Function-associated Antigen-1) on human leukocytes inhibiting consequently its binding to ICAM-1
(Bechard et al. 2001b). The expression of endocan / ESM-1 is upregulated by pro-inflammatory molecules such as tumor necrosis factor alpha (TNFa), lipopolysaccharides (LPS) and also pro-angiogenic molecules such as vascular endothelial
growth factor (VEGF), fibroblast growth factor 2 (FGF-2) (Grigoriu et al. 2006; Sarrazin et al. 2006; Maurage et al.
2009 ; Leroy et al. 2010 ; Sarrazin et al. 2010a). Endocan / ESM-1 binds via its dermatan sulfate chain to hepatocyte
growth factor/scatter factor (HGF/SF) (Bechard et al. 2001a ; Sarrazin et al. 2010a). Recently endocan / ESM-1 was
identified as a biomarker of tip cells (Strasser et al. 2010 ; Del Toro et al. 2010).  Elevated blood levels of endocan /
ESM-1 has been reported in patients with lung and kidney cancers as well as in patients with severe sepsis (Bechard et
al. 2001b; Scherpereel et al. 2003; Grigoriu et al. 2006; Scherpereel et al. 2006 ; Leroy et al. 2010). Endocan is a
biomarker of activated endothelium (Sarrazin et al. 2010b).
 
 
Main features
  • Dermatan sulfate chain / chondroitin sulfate B
  • Issued from affinity-purifed recombinant endocan / ESM-1
  • Contains the Ido pattern responsible for growth factor binding / activities
 
The dermatan / chondroitin B sulfate chains can be ordered in custom sizes (bulk).
Usage : For research use only. Not for use in diagnostic or therapeutic procedures.
 
 
 
 
References
1. Bechard et al. (2000) J. Vasc. Res. 37:417-425 (Pubmed)
2. Grigoriu et al. (2006) Clin. Cancer Res. 12:4575-4582 (Pubmed)
3. Maurage et al. (2009) Exp. Neurol. 68:836-844 (Pubmed)
4. Leroy et al. (2010) Histopathology 56:180-187 (Pubmed)
5. Sarrazin et al. (2010) J. Canc. Sci. Ther. 2:47-52 (pdf)
6. Sarrazin et al. (2010b) Glycobiology 20:1380-1388 (Pubmed)
 
 
Ordering informations
 
Catalog No.
Product Name
Size
LIDS-10U
Dermatan sulfate chains from recombinant human Endocan
10 µg
LIDS-50U
50 µg
 
 
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