Smartox Biotechnology
 
작성일 : 13-10-15
[Smartox Biotechnology] 각종 Acetylcholine Receptor Blocker Peptide Toxin(2)
αC-Conotoxin PrXA
 
화학합성의 각종 Acetylcholine Receptor Blocker Peptide Toxin(2)
 
Acetylcholine receptor 연구에 유용한 유독 생물 유래의 합성 peptide toxin 입니다. 화학합성 peptide이기 때문에
endotoxin 오염의 걱정이 없습니다.
 
 
αC-conotoxin PrXA
 
αC-Conotoxin PrXA (AlphaC-PrXA) was originally isolated from the venom of the fish-hunting Conus parius. αC-
Conotoxin PrXA is a highly specific inhibitor of the neuromuscular nAChR. It potently antagonizes mouse muscle adult
α1/β1/ε/δ nAChR subunits (IC50 = 1.8 nM) as well as fetal mouse muscle α1/β1/γ/δ nAChR subunits (IC50 =
3 nM). αC-Conotoxin PrXA competes with α-bungarotoxin for binding at the α/δ and α/γ nAChR subunit interfaces
(with higher affinity however for the α/δ subunit interface). The 3D structure of αC-Conotoxin PrXA is different from other conotoxins that target nAChR and it is most similar to Waglerin-1, a nAChR blocker isolated from a snake venom.
αC-Conotoxin PrXA is a useful tool for investigating the structure and physiological role of nAChRs.
 
Details
AA sequence:
 
Thr-Tyr-Gly-Ile-Tyr-Asp-Ala-Lys-Pro-Hyp-Phe-Ser-Cys13-Ala-Gly-Leu-Arg-Gly-Gly-Cys20-Val-
Leu-Pro-Hyp-Asn-Leu-Arg-Hyp-Lys-Phe-Lys-Glu-NH2
 
 
(Disulfide bonds between Cys13-Cys20)
Length (aa):
 
32
Formula:
C160H249N43O44S2
Molecular Weight:
 
3541.1 Da
Appearance:
 
White lyophilized solid
Solubility:
 
Water or saline buffer
CAS number:
NA
Source:
 
Synthetic
Purity rate
 
> 98 %
 
References
1. Jimenez EC. (2013) Diversity of Conus peptides that target the nicotinic acetylcholine receptors.
   Philippine Science Letters
2. Jimenez EC., et al. (2007) AlphaC-conotoxin PrXA: a new family of nicotinic acetylcholine receptor antagonists.
   Biochemistry. PubMed link
 
 
Ordering information
 
Catalog No.
Product Name
Size
  13CON016
                           αC-Conotoxin PrXA
    0.1 mg & 0.5 mg
 
* 다른 사이즈나 bulk 공급도 가능하오니 별도로 문의하여 주십시오.
 
 
▣ 관련 페이지 ; Smartox Biotechnology
 
• 기타 각종 생리활성 Peptide
  Morphiceptin / Lys-conopressin G / GsMTx4 / Obtustatin
 
• 화학 합성의 각종 Purinergic Receptor Blocker Peptide Toxin
  Purotoxin 1
 
• 화학 합성의 각종 Acetylcholine Receptor Blocker Peptide Toxin
  αC-Conotoxin PrXA /
  Waglerin 1 / α-Conotoxin MI / α-Conotoxin GI / α-Conotoxin IMI
 
• 화학 합성의 각종 TRP Channel Blocker Peptide Toxin
  GsMTx4 / Vanillotoxin 3 (VaTx3)
 
• 화학 합성의 각종 ASIC Channel Blocker Peptide Toxin
  Psalmotoxin-1 (PcTx1, Pi-theraphotoxin-Pc1a) / APETx2
 
• 화학 합성의 각종 Chloride Channel Blocker Peptide Toxin
  GaTx1 / GaTx2 / Chlorotoxin
 
• 화학 합성의 각종 Calcium Channel Blocker Peptide Toxin
  ω-agatoxin IVA / ω-CONOTOXIN GVIA(Omega conotoxin GVIA) / ω-Conotoxin MVIIC(Omega conotoxin MVIIC) /
  SNX482  Maurocalcine/Huwentoxin I/ω CONOTOXIN SO-3(Omega contoxin SO-3)/
  ω-Conotoxin MVIIA(Omega conotoxin MVIIA )
 
• 화학 합성의 각종 Potassium Channel Blocker Peptide Toxin
  Agitoxin-2 / (Dap22)-ShK / ADWX-1
  Iberiotoxin (IbTx) / Charybdotoxin / Leiurotoxin 1 / Tamapin / Guangxitoxin 1E / ShK (Stichodactyla toxin)/
  Margatoxin / HsTx1 / Apamin / TERTIAPIN-Q / Maurotoxin / Kaliotoxin-1
 
• 화학 합성의 각종 Sodium Channel Blocker Peptide Toxin
  Paurtx 3 /
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  Protoxin II (ProTx II) / Huwentoxin IV / Huwentoxin I / μ Conotoxin PIIIA  (mu conotoxin PIIIA)