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작성일 : 13-08-05
[Lunginnov] Human recombinant Endocan / ESM-1 20 kDa
Human recombinant Endocan / ESM-1 20 kDa
 
The core protein of endocan / human ESM-1 has an apparent molecular weight of 20 kDa, when devoids of its glycan
chain of dermatan sulfate.
 
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Informations
  • Biomolecules : Endocan
  • Application : Bioassay, WB 
  • Format : 50 µg
  • Source :  Human 
* The human recombinant Endocan can be ordered in custom sizes (bulk).
 
 
클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요
 
 
Background
Endocan also known as endothelial cell-specific molecule (ESM-1) is a biomarker of endothelial dysfunction (Sarrazin et al. 2010a). This proteoglycan of 50 kDa is overexpressed by vessels in some cancers such as lung cancer, liver cancer, brain cancer and kidney cancer (Grigoriu et al. 2006 ; Chen et al. 2010 ; Maurage et al. 2009 ; Leroy et al. 2010). The
expression of endocan / ESM-1 is upregulated by pro-inflammatory molecules such as tumor necrosis factor alpha (TNFa), lipopolysaccharides (LPS) and also pro-angiogenic molecules such as vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF-2) (Leroy et al. 2010). Endocan has been recently described as a biomarker of tip cells in
neoangiogenesis (Strasser et al. 2010; Del Toro et al. 2010 ; Recchia et al. 2010).
 
 
Main Features
  • Core protein of endocan / human ESM-1
  • PM: 20 kDa
  • Devoids of the chain of dermatan / chondroitin sulfate (DS/CS) type
* This product is "for research use only and are not intended for diagnostic or therapeutic use".
 
 
References
Bechard et al. (2000) J. Vasc. Res. 37:417-425 ((Pubmed)
Grigoriu et al. (2006)  Clin. Cancer Res. 12:4575-4582 (Pubmed)
Maurage et al. (2009)  Exp. Neurol. 68:836-844 (Pubmed)
Leroy et al. (2010) Histopathology 56:180-187 (Pubmed)
Sarrazin et al. (2010a) J. Cancer. Sci.  Ther. 2:47-52 (PDF)
 
 
Ordering informations
 
Catalog No.
Product Name
Size
LIP-1002-10U
Human recombinant Endocan / ESM-1 20 kDa
10 µg
LIP-1002-50U
50 µg
 
* 50 kDa의 제품도 있습니다.
 
 
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