Smartox Biotechnology
 
작성일 : 13-07-22
[Smartox Biotechnology] 기타 각종 생리활성 Peptide
Morphiceptin / Lys-conopressin G / GsMTx4 / Obtustatin
 
기타 각종 생리활성 Peptide
화학합성 peptide이기 때문에 endotoxin 오염의 걱정이 없습니다.
 
 
Morphiceptin
 
Morphiceptin is a four amino acid peptide derived from the ß-casomorphin, a protein fragment itself derived from the
digestion of milk protein casein. It is one of the most selective agonist for µ-opoid receptors.
 
Details
AA sequence:
 
Tyr-Pro-Phe-Pro-NH2
Length (aa):
 
4
Formula:
 
C28H35N5O5
Molecular Weight:
 
521.64. Da
Appearance:
 
White lyophilized solid
Solubility:
 
Water and saline buffer
CAS number:
 
87777-29-5
Source:
 
Synthetic
Purity rate
 
> 97 %
 
References
1. Chang KJ et al. Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu)
   receptors. Science.
 
 
Lys-conopressin G
 
Lys-conopressin G was isolated from conus imperialis. This vasopressin-like peptide induces scratching and grooming
behavior when injected into mice.

 

Details
AA sequence:
 
Cys1-Phe-Ile-Arg-Asn-Cys6-Pro-Lys-Gly-NH2
 
 
(Disulfide bond between Cys1-Cys6)
Length (aa):
 
9
Formula:
C44H70N15O10S2
Molecular Weight:
 
1033.26 Da
Appearance:
 
White lyophilized solid
Solubility:
 
Water and saline buffer
CAS number:
-
Source:
 
Synthetic
Purity
 
  > 97 %
 
Reference
1.Nielsen DB, et al. (1994) Isolation of Lys-conopressin-G from the venom of the worm-hunting snail, Conus imperialis.
  Toxicon. PubMed link
2. Lourdes J. et al. (1987) Characterization of peptides from conus geographus and conus striatus venoms.
  J Biol Chem. PubMed link

 

 
GsMTx4
 
GsMTx4 has been isolated from the venom of the spider Grammostola rosea. This cationic hydrophobic polypeptide blocks mechanosensitive ion channels such as TRPC1 or TRPC6, without having any effect on whole-cell voltage-sensitive
currents. This toxin acts by perturbing the interface between the channel and the lipid bilayer without necessarily being
in physical contact with the channel. GsMTx4 also demonstrated to active TRPA1 channel at 1µM concentration.
 
 Details
AA sequence:
 
 H-Gly-Cys2-Leu-Glu-Phe-Trp-Trp-Lys-Cys9-Asn-Pro-Asn-Asp-Asp-Lys-Cys16-Cys17-Arg-Pro-
Lys-Leu-Lys-Cys23-Ser-Lys-Leu-Phe-Lys-Leu-Cys30-Asn-Phe-Ser-Phe-NH2
 
 
(Disulfide bond between Cys2-Cys17 ,  Cys9-Cys23 and Cys16-Cys30)
Length (aa):
 
34
Formula:
C185H273N49O45S6
Molecular Weight:
 
4095.2 Da
Appearance:
 
White lyophilized solid
Solubility:
 
Water and saline buffer
CAS number:
-
Source:
 
Synthetic
Purity
 
  > 97 %
 
citiation
1. Anderson M, et al. (2013) Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by
   membrane stretch or diacylglycerol. Am J Physiol Cell Physiol. PubMed link
 
Reference
1.Bae, C.,  et al. (2011) The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4. Biochemistry.
2. Kerstin Hill, Michael Schaefer (2007) TRPA1 Is Differentially Modulated by the Amphipathic Molecules Trinitrophenol and
   Chlorpromazine. JBC. PubMed link
3. Ruta, V., and MacKinnon, R. (2004) Localization of the voltage-sensor toxin receptor on KvAP, Biochemistry.
4. Ostrow, K. L., et al. (2003) cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of
   mechanosensitive channels. Toxicon. PubMed link
5. Oswald, R. E., et al. (2002) Solution structure of peptide toxins that block mechanosensitive ion channels.
   J Biol Chem. PubMed link
6. Suchyna, T. M., et al. (2000) Identification of a peptide toxin from Grammostola spatulata spider venom that blocks
   cation-selective stretch-activated channels. J Gen Physiol. PubMed link
 
 
Obtustatin
 
Obtustatin is a 41 amino acid disintegrin peptide isolated from the venom of the Vipera lebetina obtusa. It is a potent
(IC50 = 2 nM) and selective inhibitor of the binding of α1β1 integrin to collagen IV.  Contrary to other known disintegrins, it does not contain the classical RGD sequence. Does not show inhibitory activity toward other integrins, including α2β1,
αIIbβ3, αvβ3, α4β1, α5β1, α6β1, and α9β1, α4β7 integrins. Obtustatin potently inhibits angiogenesis in chicken and in
mouse model and reduces tumor development by half.
 
Details
AA sequence:
 
Cys1-Thr-Thr-Gly-Pro-Cys6-Cys7-Arg-Gln-Cys10-Lys-Leu-Lys-Pro-Ala-Gly-Thr-Thr-Cys19-Trp-
Lys-Thr-Ser-Leu-Thr-Ser-His-Tyr-Cys29-Thr-Gly-Lys-Ser-Cys34-Asp-Cys36-Pro-Leu-Tyr-Pro-Gly-OH
 
 
(Disulfide bond between Cys1-Cys10 ,  Cys6-Cys29 , Cys7-Cys34 and Cys19-Cys36)
Length (aa):
 
41
Formula:
C184H284N52O57S8
Molecular Weight:
 
4393.13 Da
Appearance:
 
White lyophilized solid
Solubility:
 
aqueous buffer
CAS number:
not available
Source:
 
Synthetic
Purity
 
  > 97 %
 
Reference
1.Daidone I, et al. (2013) Structural and dynamical properties of KTS-disintegrins: A comparison between Obtustatin and
   Lebestatin. Biopolymers.
2. Brown MC, et al. (2008) Angiostatic activity of obtustatin as alpha1beta1 integrin inhibitor in experimental melanoma
   growth. Int J Cancer.
3. Calvete JJ, et al. (2007) KTS and RTS-disintegrins: anti-angiogenic viper venom peptides specifically targeting the
   alpha 1 beta 1 integrin. Curr Pharm Des.
4. Moreno-Murciano M.P., et al. (2003) Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-
   containing short disintegrin isolated from the venom of Vipera lebetina obtusa. Protein Sci.
5. Marcinkiewicz C., et al. (2003) Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and angiogenesis
   in vivo. Cancer Res.
6. Moreno-Murciano M.P., et al. (2003) NMR solution structure of the non-RGD disintegrin obtustatin. J. Mol. Biol.
 
 
Ordering informations
 
Catalog No.
Product Name
Size
  011CAS001
                             Morphiceptin
5 mg &
10 mg
  11CON014
  Lys-conopressin G
0.5 mg &
1.0 mg
  08GSM001
GsMTx4
0.05 mg, 0.1 mg
& 0.5 mg
  10OBT001
                              Obtustatin
0.1 mg, 0.5 mg
& 1.0 mg
 
* 다른 사이즈나 bulk 공급도 가능하오니 별도로 문의하여 주십시오.
 
 
▣ 관련 페이지 ; Smartox Biotechnology
 
• 화학 합성의 각종 Purinergic Receptor Blocker Peptide Toxin
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• 화학 합성의 각종 Chloride Channel Blocker Peptide Toxin
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• 화학 합성의 각종 Calcium Channel Blocker Peptide Toxin
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  Maurocalcine/Huwentoxin I/ω CONOTOXIN SO-3/Omega contoxin SO-3/ω-Conotoxin MVIIA/Omega conotoxin MVIIA
 
• 화학 합성의 각종 Potassium Channel Blocker Peptide Toxin
  Iberiotoxin (IbTx) / Charybdotoxin / Leiurotoxin 1 / Tamapin / Guangxitoxin 1E / ShK (Stichodactyla toxin)/
  Margatoxin / HsTx1 / Apamin / TERTIAPIN-Q / Maurotoxin / Kaliotoxin-1
 
• 화학 합성의 각종 Sodium Channel Blocker Peptide Toxin
  Protoxin I (ProTx-1) / GsAF-I / GsAF-II / Jingzhaotoxin III / Biotinyl-Protoxin II (ProTx II) /  Hainantoxin-IV /
  Protoxin II (ProTx II) / Huwentoxin IV / Huwentoxin I / μ Conotoxin PIIIA / mu conotoxin PIIIA