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작성일 : 20-05-26
[Etc] dPEGs, Homobifunctional
dPEGs(discrete polyethylene glycols), Homobifunctional

 

dPEGs(discrete polyethylene glycols), Homobifunctional

 

Bis-Bromoacetamido-dPEG®11

 

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Bis-Bromoacetamido-dPEG®11, product number 11338, is a thiol-reactive, homobifunctional crosslinker, with

the two reactive ends separated by a single molecular weight, discrete polyethylene glycol (dPEG®) spacer

that is 44 atoms long (47.5 Å). Both ends of the dPEG® spacer terminate with bromoacetyl groups that

connect to the dPEG® cross-bridge through amide bonds.

 

Bis-dPEG®11-DBCO

 

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Bis-dPEG®11-DBCO, product number 11372, is a click chemistry reagent consisting of two

dibenzylcyclooctyne (DBCO) groups separated by a single molecular weight, discrete polyethylene glycol

(dPEG®) spacer that is 39 atoms (44.2 Å) long. The total length of the molecule is 55 atoms (67.2 – 68.2 Å)

long. The DBCO groups react with azide groups via the bioorthogonal clickchemistry reaction known as

strain-promoted azide-alkyne cycloaddition (SPAAC), also known as copper-free click chemistry. This

product is particularly useful for click chemistry reactions where the presence or use of copper(I) [Cu(I)] is

undesirable

 

Bis-MAL-dPEG®3

 

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Bis-MAL-dPEG®3, product number 10215, is a short, homobifunctional, crosslinking reagent that links two

molecules (e.g., peptides, proteins) together via the thiol-maleimide reaction (also known as the thiol-

Michael addition). Maleimidopropionate groups functionalize each end of the molecule. A short, single

molecular weight, discrete polyethylene glycol (dPEG®) spacer separatesthe two end groups. The end-to-

end length of the molecule is 27 atoms (about 30 Å).

 

Bis-MAL-dPEG®11

 

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Bis-MAL-dPEG®11, product number 10397, is a medium-length, homobifunctional, crosslinking reagent that

links two molecules (e.g., peptides, proteins) together via the thiol-maleimide reaction (also known as the

thiol-Michael addition). The ends of the molecule are both functionalized with maleimidopropionate groups.

The two reactive ends are separated by a single molecular weight, discrete polyethyleneglycol (dPEG®)

spacer that is 37 atoms (46.9 – 47.9 Å) long. The end-to-end length of the molecule is 49 atoms (62.3 – 63.3

Å).Read More

 

Diamido-dPEG®11-diamine

 

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Diamido-dPEG®11-diamine, product number 10361, is a homobifunctional, water-soluble crosslinker. Both

ends of the crosslinker terminate with amino groups. Carboxyl groups react with the crosslinker's amines to

form stable amide bonds. Aldehydes and ketones react to form Schiff bases. Reduce Schiff bases to

secondary amines for improved bond stability. The cross-bridge of this molecule consistsof a single

molecular weight, discrete chain length polyethylene glycol (dPEG®) linker. The dPEG®linker is 49 atoms

long and spans a distance of 57.1 Å. This molecule is useful for modifying carboxylic acid-functionalized

surfaces, small molecules with reactive carbonyl groups, and carbohydrates containing reducing sugars.

 

 

Ordering informations

    

Catalog No.

Product Name

Size

11338

Bis-Bromoacetamido-dPEG ®11

50 mg & 1000 mg

11372

Bis-dPEG ®11-DBCO

25 mg, 100 mg & 500 mg

10215

Bis-MAL-dPEG®3

50 mg & 1000 mg

10397

Bis-MAL-dPEG®11

50 mg & 1000 mg

10361

Diamido-dPEG®11-diamine

100 mg & 500 mg

 

 

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