Spinal Motor Neurons
BrainXell focuses on human neural cells for therapeutic development. It is based on the proprietary
technology for directed differentiation of human stem cells (including induced pluripotent stem cells) to highly
enriched subclasses of neural progenitors, expansion of committed neural progenitors to large quantities,
and rapid maturation to functional neurons and glia. BrainXell's goal is to make our brain healthy and well.
BrainXell's motor neurons are >95% neurons and show >70% motor neuron identity. The presence of
astrocytes or other glia is undetectable.
By one week in culture, spontaneous firing can be observed that increases over the next two weeks,
BrainXell's iPSC derived motor neurons are extremely pure, fast maturing, and robust.
• Neuronal Purity: >90%
• Time to Use: 5-10 Days
• Evaluation Size 1 Million Cells available
• GFP Reporter Available for Standard and Evaluation Sizes (BX-0101, BX-0101e)
Figure 1. Expression of Motor Neuron Markers
(A-C)Neurons express markers associated with spinal motor neuron identity, including MNX1, FoxP1 and
ChAT.(D) Approximately 60-65% of motor neurons are positive for the mature neuronal marker NeuN. (E-F)
Extensive neurite outgrowth, which begins within a day of plating, is shown by calcein AM staining and