Controlled delivery Pronanosomes (Thermo/Thermosensitive)
42 ~ 43℃에서 nanovesicle이 붕괴되어 내포된 물질이 방출됩니다.
Pronanosome은 ready-to-use의 liposome, niosome 및 thermosensitive nanovesicles 준비를 위한 제품입니다.
1 회분 시약이 들어있는 유리병에 목적물질을 첨가하는 등 간단한 조작으로 목적물질을 내포한 liposome 및
niosome 등을 만들 수가 있습니다.
Pronanosomes are ready- to-use formulations to obtain encapsulating nanovesicles in a fast and easy way.
Nanovesicles formed from Pronanosomes are able to encapsulate a wide variety of compounds as
hydrophlic or lipophilic molecules, peptides, enzymes and proteins, among others. In addition, nanovesicles
have a great stability, an easily controllable size and great entrapment efficiencies. A complete protocol of
use is attached with the product, if you still have questions or need more information about the product, we
help you. Nanovex Biotechnologies offers free advice for all products.
Nanovesicles obtained from Pronanosomes have multiple applications such as,
• Drug delivery and targeting
• Delivery of peptide drugs and proteins
• Studying Inmune response
• (Trans)dermal drug delivery systems
• Nutraceuticals and food applications
Pronanosome Thermois a ready-to-use formulation specially designed to obtain thermosensitive
nanovesicles, which are able to release their content above 40-42 ℃ or pH values lower than 5.5.
Pronanosome Thermo can be used in several applications when a controlled delivery of the encapsulated
compound with temperature is needed. The main application of Pronanome Thermo is drug delivery,
although the product has other applicatios such as,
Studying of inmune response, dermal or transdermal delivery, cosmetics, functional foods, smart labelling &
Liposome characteristics depending on the preparation method from Pronanosome Thermo. In order to
obtain the best results, a sonication of the sample (using a probe or a bath) is recommended to achieve
small unilamellar nanovesicles.
Carboxyfluorescein realase at 37℃ & 42℃
Standard Pronanosomes are formulations to obtain, in a fast and easy way, nanovesicles able to
encapsulate a wide variety of compounds. In addition, standard Pronanosomes can be used in different
applications such as drug delivery, foods and cosmetics.
Intracellular/in vitro(cationic) Pronanosomes
Intracellular/in vitro Pronanosomes are formulations to obtain, in a fast and easy way, nanovesicles
positively charged which are endocyted by cells to achieve intracellular delivery. This Pronanosomes can be
ordered with other characteristics such as PEGylated (for Intracellular in vivo assays), fluorescent or
Bioconjugable pronanosomes (Bioconjugable-COOH & Bioconjugable-Maleimide)
Bioconjugable nanovesicles can be conjugated with several biocompounds such as proteins, enzymes and
antibodies among others. Pronanosome bioconjugable series have several applications, among which the
following are of note,
• Active targeting of drug (drug/protein/peptide, etc.) loaded liposome
Fluorescent Pronanosomes (Pronasome - GF)
Fluorescent nanovesicles are very useful to in vivo/in vitro/in situ/ex vivo nanovesicle detection.
Pronanosome green fluorescence series allow to obtain fluorescently labelled nanovesicles (Green
fluorescence) in a fast and easy way.
In vivo Pronanosomes (Pronanosome PEGylated/Stealth)
Nanovesicles containing PEG on the surface has been shown to extend blood-circulation time while
reducing mononuclear phagocyte system uptake (stealh nanovesicles). PEGylated nanovesicles have high
stability due the sterical repulsion. The presence of PEG on the surface of the nanovesicles has been
shown to extend blood-circulation time while reducing mononuclear phagocyte system uptake (stealth
nanovesicles). This technology has resulted in a large number of nanovesicle formulations encapsulating
active molecules, with high target efficiency and activity. Speciallysuited to “in vivo” assays.
How to choose the appropriate nanovesicle