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작성일 : 17-03-28
[Cellagen Technology LLC] Disease Area, Ophthalmology

 

Disease Area, Ophthalmology

 

 

Product Name: Latanoprost | Prostaglandin F receptor (FP) agonist

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Latanoprost is a potent and selective agonist of Prostaglandin F receptor (FP). It activates FP, a G-protein

coupled receptor (GPCR), with EC50 of 10 nM, and with at least 500-fold selectivty over other Prostaglandin

receptors. Upon activation, FP promotes the decrease of intraocular pressure and contraction of smooth

muscle.

 

Clinically, Latanoprost (aka Xalatan(r)) is used as a topical ophthalmic solution for controlling the

progression of glaucoma or ocular hypertension by increasing the outflow of aqueous fluid from the eyes,

therefore reducing intraocular pressure.

 

Details

Chemical Formula:

 

C26H40O5

CAS No.:

 

130209-82-4

Molecular Weight:

 

432.59

Purity:

 

> 98%

Appearance:

 

clear oil

Chemical Name:

 

 

(Z)-isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)

cyclopentyl)hept-5-enoate

Solubility:

 

Up to 100 mM in DMSO

Synonyms:

 

latanoprost, Xalatan®

Storage:

 

 

For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution

at -20oC.

 

References

1. Stjernschantz et al., From PGF2?-isopropyl ester to latanoprost: a review of the development of xalatan:

   the Proctor Lecture. Invest.Ophthalmol.Vis.Sci. 2001, 42(6):1134-45.

2. Camras CB et al., Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after

   1 year of treatment in 198 patients. Latanoprost Study Groups. Ophthalmology. 1996, 103(11):1916-24.

  

 

Product Name: LX7101 |LIMK2 inhibitor

 

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LX7101 is a pyrrolopyrimidine-based, topically-delivered inhibitor of LIM domain kinase 2 (LIMK2), a kinase

associated with the regulation of intraocular pressure. LX7101 acts by enhancing fluid outflow through the

trabecular meshwork of the eye. Preclinical studies indicate that LX7101 significantly reduced intraocular

pressure in both mouse and monkey models. LX7101 recently completed a randomized, double-blind,

placebo-controlled Phase 1/2a trial for patients with open angle glaucoma or ocular hypertension.

 

Details

Chemical Formula:

 

C23H30ClN7O3

CAS No.:

 

1192189-69-7

Molecular Weight:

 

487.98

Purity:

 

> 98%

Appearance:

 

White

Chemical Name:

 

 

3-(4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-

carboxamido)phenyl dimethylcarbamate hydrochloride  

Solubility:

 

Up to 20 mM in DMSO

Synonyms:

 

LX-7101. LX7101

Storage:

 

 

For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution

at -20oC.

 

References

1. Lexicon Genetics webpage

2. www.clinicaltrials.gov webpage for LX7101 Phase 1/2a trials (completed 8/12)

 

 

Ordering informations   

Catalog No.

Product Name

Size

C5282

Latanoprost l Prosaglandin F receptor (FP) agonist

2 mg, 10 mg & 50 mg

C5971

LX7101 l LIMK2 inhibitor

2 mg, 10 mg & 50 mg

 

 

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