Apotosis Inducers sets
Apoptosis is commonly defined as programmed mechanism of cell death and is a highly regulated process
that can be initiated by a variety of internal and external stimuli (inducers). G‐Biosciences’ Apoptosis
Inducers are ready‐to‐use solutions for inducing apoptosis in various cell types. They are supplied
individually as well as in a set of 6 inducers. These inducers include: Actinomycin D, Camptothecin,
Cycloheximide, Dexamethasone, Doxorubicin and Etoposide and can be used in 1000X dilution. These
agents induce apoptosis by different mechanisms. Depending on the need, individual as well as set of
inducers may be ordered.
A class of polypeptide antibiotics isolated from the Steptomyces soil bacteria. Actinomycin D inhibits
transcription by binding to DNA at the transcription initiation complex and therefore preventing elongation by
the RNA polymerase.
• Synonym : Dactinomycin
• CAS Number : 50-76-0
• Linear Formular : C62H86N12O16
• Molecular Weight : 1255.42
• Bancos, S. et al (2010) Cell. Immunol. 262:18
• Fenjves, E.S. et al (2008) Cell Transplant. 17:793
• Vigneswaran, N. et al (2003) Oral Oncol. 39:559
A cytotoxic quinoline alkaloid that inhibits the DNA enzyme topoisomerase I (Topo I).
An inhibitor of protein synthesis by interfering with the translocation step (movement of two tRNA molecules
and mRNA on ribosome) in protein synthesis, thus blocking translational elongation.
A potent and stable glucocorticoid steroid hormone that is often used as an anti-inflammatory and anti-
rheumatic drug. The mechanism of action is not fully understood, however it is thought that it may inhibit
Doxorubicin (or hydroxyldaunorubicin) is an anthracycline antibiotic that intercalates DNA, inhibiting the
unwinding of DNA by topoisomerase II.
An inhibitor of topoisomerase II.
Instruction sheet (PDF)