Anti-human/mouse/rat Endocan Antibody (C-ter) MEP14
Anti-human endocan/ESM-1 monoclonal antibody called MEP14 (LIA-1001) detects the C-terminus of human, chicken,
rat, pig, mouse and monkey endocan. This monoclonal antibody is recommended for western-blot, for
immunohistochemistry and for ELISA.
- Clone : MEP14
- Epitope : C-Ter
- Format : 1 tube/100 µg
- Type : Monoclonal(mouse)
- Application : WB, IHC, ELISA
- Isotype : IgG2a, K
* The monoclonal MEP08 antibody (LIA-0901) can be ordered in custom sizes (bulk).
Anticorps anti-endocan / ESM-1 humain (C-Ter) MEP14 100 µg
Endocan also known as endothelial cell-specific molecule (ESM-1) was originally discovered by Lassalle and collaborators
in endothelial cells (Lassalle et al. 1996). Structurally, endocan is a dermatan sulfate proteoglycan of 50 kDa that is freely
circulating in blood (Bechard et al. 2001a; Delehedde et al. 2002). Endocan / ESM-1 binds CD11a/CD18 integrin (also
called LFA-1 for Leukocyte Function-associated Antigen-1) on human leukocytes inhibiting consequently its binding to
ICAM-1 (Bechard et al. 2001b). The expression of endocan is upregulated by pro-inflammatory molecules such as tumor
necrosis factor alpha (TNFa), lipopolysaccharides (LPS) and also pro-angiogenic molecules such as vascular endothelial
growth factor (VEGF), fibroblast growth factor 2 (FGF-2) (Grigoriu et al. 2006; Sarrazin et al. 2006; Maurage et al. 2009 ;
Leroy et al. 2010 ; Sarrazin et al. 2010). Endocan / ESM-1 binds via its dermatan sulfate chain to hepatocyte growth
factor/scatter factor (HGF/SF) (Bechard et al. 2001a). Elevated blood levels of endocan / ESM-1 has been reported in
patients with lung and kidney cancers as well as in patients with severe sepsis (Bechard et al. 2001b; Scherpereel et al.
2003; Grigoriu et al. 2006; Scherpereel et al. 2006 ; Leroy et al. 2010 ; Sarrazin et al. 2010).
Main Features :
- Monoclonal Antibody (mouse)
- Detect by immunoblotting a 50 kDa band corresponding of proteoglycan
- Detect the C-terminus of human, monkey, swine, chicken, mouse and rat endocan
- Recommended reference for immunoblotting (WB), immunohistochemistry (IHC) and ELISA
* This product is "for research use only and are not intended for diagnostic or therapeutic use".
Bechard et al. (2000) J. Vasc. Res. 37:417-425 ((Pubmed)
Grigoriu et al. (2006) Clin. Cancer Res. 12:4575-4582 (Pubmed)
Maurage et al. (2009) Exp. Neurol. 68:836-844 (Pubmed)
Leroy et al. (2010) Histopathology 56:180-187 (Pubmed)
Sarrazin et al. (2010a) J. Cancer. Sci. Ther. 2:47-52 (PDF)