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작성일 : 15-02-24
[Array Bridge] EnbrBridge Elisa kit, Enbrel biosimilar comparison

 

EnbrBridge Elisa kit (for Enbrel biosimilar comparison)

Complete kit for the systematic 3-D conformational comparability analysis of Enbrel biosimilar

molecule to Etanercept (Enbrel trade name)

 

 

클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요

 

 

  

Principle

 

Etanercept (trade name Enbrel) is a biopharmaceutical that treats autoimmune disease by acting as a TNF

inhibitor. It has U.S. F.D.A. approval to treat rheumatoid arthritis, juvenile rheumatoid arthritis and psoriatic

arthritis, plaque psoriasis and ankylosing spondylitis. Etanercept is a fusion protein produced by recombinant

DNA, fusing the TNF receptor to the constant region of the IgG1 antibody. Etanercept is a large molecule, with

a molecular weight of 150 kDa., that binds to TNFα anddecreases its role in disorders involving excess

inflammation in humans and other animals, including autoimmune diseases and potentially in a variety of

other disorders mediated by excess TNFα.

 

클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요

               Fig. 1  TNFα Receptor Higher Order Structure

 

클릭하시면 닫힙니다.이미지 저장을 원하시면 마우스 오른쪽클릭후 '다른이름으로 저장'을 하세요

               Fig. 2  IgG1 CH2 and CH3 Higher Order Structure

 

 

Supplied Components

  • Coated Clear 96 Well Plates
  • 5x Dilution Buffer
  • 10x PBS-T
  • Reporting antibody
  • Streptavidin-HRP Conjugate
  • TMB Substrate
  • Stop Solution
  • Plate Sealer

 

 

Product information  (PDF)

 

 

Ordering information

Catalog No.

Target

Size

AB000211

 Anti-human IgG ELISA kit

1 kit & 5 kits

 

 

▣ 관련 페이지 ; Array Bridge  (바이오시밀러/Biosimilar 구조 평가 ELISA kits, etc.)