FormuMax Scientific
 
작성일 : 14-12-12
[FormuMax Scientific] Doxoves™ - Liposomal Doxorubicin HCl, New 2mg/mL

 

Doxoves™ - Liposomal Doxorubicin HCl, New 2mg/mL

 

 

항종양 활성을 갖는 항생물질 Doxorubicin HCl을 내포한 liposome입니다. Doxorubicin HCl을 liposome 내에 내포

시킴으로써 pharmacokinetics/pharmacodynamics(PK/PD)적인 작용이 개선됩니다.

입경이 균일하기 때문에 lot 간의 차이가 적은 고품질로서, 높은 봉입 효율을 보이도록 조제되어 있습니다.

Doxorubicin HCl이 없는 control용 liposome도 있습니다.

* Doxorubicin은, reverse transcriptase, RNA polymerase의 활성을 억제하는 항생물질입니다. Intercalation에

의해 이중 가닥 DNA에 결합하여, DNA의 복제·전사를 억제하는 것으로 생각되고 있으며, 세포 사멸을 유도합니다.

 

 

Cryo-EM of FormuMax's liposome doxorubicin HCl (F30204B-D) (Image taken by NanoImaging Services Inc.)

 

 

FormuMax has been providing custom-made formulations of liposomal doxorubicin HCl with various lipid

compositions and particle sizes. There has been an increased demand of liposomal doxorubicin

comparable to the commercial Doxil®. Now we are proudly naming our product, Doxoves®, and making it

available to you at an affordable price.

 

Doxoves®is manufactured to high quality with consistent lot-lot characteristics, tight particle size distribution

and high drug encapsulation efficiency.  A high drug concentration of 4.0 mg/mL (40mM lipid) allows

researchers to perform experiments athigher concentrations/doses. Doxoves® is comparable to the

commercial product Doxil® in characteristics, stability and pharmacokinetics. Cryo-TEM studies  have

shown that the encapsulated doxorubicin forms the same type of rod-like structures as in Doxil®. A recent

PK study of two batches of Doxoves® demonstrated an excellent PK profile with t1/2 of 30-40hr similar to that

of Doxil®.

 

  

 

Good News !!!   

According to request from customers, the 2.0mg/mL liposomal doxorubicin HCl is now available.

 

 


Ordering informations


Catalog No.

Product Name

Size

F30204C-D

Combo kit of Doxoves® and the plain control liposomes

2 ml & 10 ml

F30204B-C

Control liposomes for Doxoves® (4.0mg/mL)

2 ml & 10 ml

F30204B-C2

Control liposomes for Doxoves® (2.0mg/mL)

2 ml & 10 ml

F30204B-D

Doxoves® - STEALTH Liposomal Doxorubicin HCl (4.0mg/mL)

2 ml & 10 ml

F30204B-D2

Doxoves® - STEALTH Liposomal Doxorubicin HCl (2.0mg/mL)

2 ml & 10 ml

FB30020

Dilution Buffer for Doxoves™

2 ml & 10 ml

 

 


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