Smartox Biotechnology
 
작성일 : 14-11-24
[Smartox Biotechnology] Inhibitor of the binding of α1β1 integrin to collagen IV
Obtustatin

 

 

Obtustatin, Inhibitor of the binding of α1β1 integrin to collagen IV

Desintegrins are potent inhibitors of integrin cell-dependent adhesion

 

 

Obtustatin is a 41 amino acid disintegrin peptide isolated from the venom of the Vipera lebetina obtusa. It is a

potent (IC50 = 2 nM) and selective inhibitor of the binding of α1β1 integrin to collagen IV. Contrary to other

known disintegrinse, it does not contain the classical RGD sequence. Obtustatin does not show inhibitory

activity toward other integrins, including α2β1, αIIbβ3, αvβ3, α4β1, α5β1, α6β1, and α9β1, α4β7 integrins. 

Obtustatin potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development

by half.

 

Details

AA sequence:

 

 

Cys1-Thr-Thr-Gly-Pro-Cys6-Cys7-Arg-Gln-Cys10-Lys-Leu-Lys-Pro-Ala-

Gly-Thr-Thr-Cys19-Trp-Lys-Thr-Ser-Leu-Thr-Ser-His-Tyr-Cys29-Thr-Gly-

Lys-Ser-Cys34-Asp-Cys36-Pro-Leu-Tyr-Pro-Gly-OH

 

Disulfide bonds:

 

 

Cys1-Cys10, Cys6-Cys29, Cys7-Cys34 and Cys19-Cys36

 

Length (aa):

 

 

41

 

Formula:

 

 

C184H284N52O57S8

 

Molecular Weight:

 

 

4393.13. Da

 

Appearance:

 

 

White lyophilized solid

 

Solubility:

 

 

Aqueous buffer

 

Source:

 

 

Synthetic

 

Purity rate

 

 

> 97 %

 

 

Reference

1. Daidone I, et al. (2013) Structural and dynamical properties of KTS-disintegrins: A comparison between Obtustatin and Lebestatin. Biopolymers. PMID: 23097229

 

 

Ordering information

Catalog No.

Product Name

Size

10OBT001

Obtustatin

0.1 mg, 0.5 mg & 1.0 mg

 

 

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