Hypermol EK
 
작성일 : 14-11-20
[Hypermol EK] Actin Binding Protein, Thymosin beta-4

 

Actin Binding Protein, Thymosin beta-4

Small but mighty !

 

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Thymosin beta-4 sequester actin monomers and form 1:1 complexes

with G-actin, maintaining the pool of unpolymerized actin

 

It is supplied in a stable form as lyophilized protein, fully functional

after reconstitution.

 

 

Thymosin beta-4

 

Description

Protein

 

 

Thymosin beta-4 (Synonyms: T beta 4, Fx, TB4X, PTMB4, TMSB4)

 

Origin

 

 

Recombinant, human recombinant - untagged.

 

Molecular mass

 

 

5kDa

 

Protein description

 

 

 

 

 

 

 

Thymosin is a hormone secreted from the thymus. The predominant form of

thymosin, thymosin b4, is a member of a highly conserved family of actin monomer

sequestering proteins. b-thymosins are the primary regulators of unpolymerized

actin, and are essential for maintaining the small cytoplasmic pool of free G-actin

monomers required for rapid filament elongation and allowing for the flux of

monomers betweenthe thymosin bound pool and F-actin.

 

Actin interaction

 

 

 

 

 

The predominant form of thymosin, thymosin b4, is a member of a highly conserved

family of actin monomer sequestering proteins. b-thymosins are the primary

regulators of unpolymerized actin, and are essential for maintaining the small

cytoplasmic pool of free G-actin monomers required for rapid filament elongation and

allowing for the flux of monomers between the thymosin bound pool and F-actin

 

Properties

Form

 

 

Lyophilized, ready-to-use

 

Quantity

 

 

2 x 50 µg & 1.0 mg

 

Buffer

 

 

 

5mM Tris pH 8.1, 0.1mM DTT and 0.2% sucrose, when reconstituted with 50 µl

ultrapure water to obtain a 1.0mg/ml solution.

 

Purity

 

 

>98% by RT-HPLC.

 

Purification notes

 

 

 

Thymosin beta-4 protein was expressed in E.coli and further purified by Affinity

Chromatography (polyproline column). The pure protein was yielded by gel

filtration.

 

Protein conc.

 

 

Determined by RT-HPLC.

 

Storage instructions

 

 

 

 

 

Thymosin beta-4 is stored at -70°C upon arrival will be stable in performance for at

least 6 months from the date of purchase. The solubilized protein is kept on ice and

should be stored at -20°C in glycerol or CryoProtect (Cat.#: 6011-01).

Avoid repeated freeze / thaw cycles.

  

Shipping conditions

 

 

At ambient temperature. Upon delivery store at -70°C.

 

Remarks

 

 

For Use in Research only. Not for Use in Human or Veterinary Diagnostical or

Therapeutical applications.

 

Ordering informations

Catalog No.

Product Name

Size

8422-01

Actin Binding Protein, Thymosin beta-4

2 x 50 µg

8422-02

1.0 mg

 

 

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