Hypermol EK
 
작성일 : 14-11-18
[Hypermol EK] Actin Binding Protein, Filamin

 

Actin Binding Protein, Filamin

The secret of Flexibility

 

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... from turkey gizzard is a homodimer, consisting of

24 repeats of ~96 amino acids and an N-terminal

actin binding sequence.

Filamin crosslinks actin filaments into orthogonal

networks.The C-terminal end of each Filamin

monomer is characterized by a hinge region,

responsible for the flexibility of actin networks.

 

 

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             Actin networks

 

   Filamin : Atto488-Actin ( 1:12 M/M)

 

 

Actin Binding Protein

 

Description

Protein

 

 

Filamin (Filamin A)

 

Origin

 

 

smooth muscle, turkey

 

Molecular mass

 

 

546kDa

 

Protein description

 

 

 

 

 

Filamin from turkey gizzard is a homodimer (2x273kDa) with a molecular mass of

546kDa, consisting of 24 repeats of ~96 amino acids and an N-terminal actin binding

sequence. Filamin crosslinks actin filaments into orthogonal networks.

The C-terminal end of each Filamin monomer is characterized by a hinge region,

responsible for the flexibility of actin networks.

 

Actin interaction

 

 

Actin cross linking protein. Kd actin-binding = 0.5µM.

 

Properties

Form

 

 

Lyophilized, ready-to-use

 

Quantity

 

 

100 µg

 

Buffer

 

 

 

10mM NaCl, 20mM Tris pH 7.4, 0.5mM DTT and 2.4% disaccharides,

when reconstituted with 1.0ml ultrapure water to obtain a 1.0 mg/ml solution.

 

Purity

 

 

>95% by scanning densitometry from Coomassie G-250 stained SDS-Gels.

 

Purification notes

 

 

Purified from turkey gizzard muscle.

 

Protein conc.

 

 

Determined by OD280 (0.1%=0.64).

 

Storage instructions

 

 

upon reconstitution the product is stored on ice. This product can also be stored as

a glycerol stock at -20°C. Avoid repeated freeze / thaw cycles.

Shipping conditions

 

 

At ambient temperature. Upon delivery store at -70°C.

 

Remarks

 

 

For Use in Research only. Not for Use in Human or Veterinary Diagnostical or

Therapeutical applications.

 

 

Actin Binding Protein

         

Description

Protein

 

 

Filamin (Filamin A)

 

Origin

 

 

Smooth muscle, turkey

 

Molecular mass

 

 

546kDa

 

Protein description

 

 

 

 

 

Filamin from turkey gizzard is a homodimer (2x273kDa) with a molecular mass of

546kDa, consisting of 24 repeats of ~96 amino acids and an N-terminal actin binding

sequence. Filamin crosslinks actin filaments into orthogonal networks.

The C-terminal end of each Filamin monomer is characterized by a hinge region,

responsible for the flexibility of actin networks.

 

Actin interaction

 

 

Actin cross linking protein. Kd actin-binding = 0.5µM.

 

Properties

Form

 

 

Lyophilized, ready-to-use

 

Quantity

 

 

1.0mg

 

Buffer

 

 

 

10mM NaCl, 20mM Tris pH 7.4, 0.5mM DTT and 2.4% disaccharides,

when reconstituted with 1.0ml ultrapure water to obtain a 1.0 mg/ml solution.

 

Purity

 

 

>95% by scanning densitometry from Coomassie G-250 stained SDS-Gels.

 

Purification notes

 

 

Purified from turkey gizzard muscle.

.

Protein conc.

 

 

Determined by OD280 (0.1%=0.64).

 

Storage instructions

 

 

 

upon reconstitution the product is stored on ice. This product can also be stored as

a glycerol stock at -20°C. Avoid repeated freeze / thaw cycles.

 

Shipping conditions

 

 

At ambient temperature. Upon delivery store at -70°C.

 

Remarks

 

 

For Use in Research only. Not for Use in Human or Veterinary Diagnostical or

Therapeutical applications.

 

Ordering informations

Catalog No.

Product Name

Size

8312-01

Actin Binding Protein, Filamin

1 x 50 µg, 5 x 50 µg

8312-02

Actin Binding Protein, Filamin

1 x 1.0 mg, 5 x 1.0 mg

 

 

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