Research Article Cites Cleanascite™ for Alzheimer’s Disease Biomarkers
MONMOUTH JUNCTION, N.J. – Sept. 17, 2015 – PRLog — MONMOUTH JUNCTION, NJ — Biotech Support
Group reports on a recent research article describing the simplicity and efficiency of their proteomic sample
preparation technology for clearing lipoproteins from human sera.
The citation is:
John A. McIntyre, Curtis J. Ramsey, Bruce D. Gitter,Andrew J. Saykin, Dawn R. Wagenknecht, Paul A. Hyslop.
Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer’s disease.
Autoimmunity, 2015; 48(5): 344-351. DOI: 10.3109/08916934.2015.1008464
In brief, the article’s authors aimed at identifying new biomarkers for early diagnosis of Alzheimer’s disease,
by ELISA measurement of redox reactive autoantibodies (R-RAAs) antiphospholipid antibodies. The article
states “Aliquots of the 90 ADNI serum samples were thawed and treated with Cleanascite™ (Biotech Support
Group) at a serum: Cleanascite™ ratio of 4:1 v/v in 2 ml micro centrifuge tubes with gentle rocking at 37°C for
10min followed by centrifugation for 1 min at 16 000g. Treatment with Cleanascite™ removes lipoproteins from
the serum, which have been shown to bind and undergo oxidation with hemin.”
“This is an excellent example of how Cleanascite™ can improve ELISA measurements. Clearly, there was
necessity for removing lipoproteins without compromising the quantity or quality of the autoantibodies present
and to be measured. The exquisite selectivity profile of Cleanascite™ makes this possible.” states Swapan
Roy, Ph.D., President and Founder of Biotech Support Group.
For more information visit: Cleanascite™ Lipid Removal Reagent and Clarification, at
About Biotech Support Group LLC
Biotech Support Group LLC is a leading provider of proteomic, metabolomic and genomic sample preparation
and enrichment products and services. It’s principal products include: AlbuVoid™ & AlbuSorb™ for albumin
depletion, Cleanascite™ for lipid adsorption and clarification, HemogloBind™ & HemoVoid™ for hemoglobin
removal, NuGel™ for functional & chemical proteomics, and ProCipitate™ for nucleic acid isolation. For more
information, go to http://www.biotechsupportgroup.com