Journal Article Cites HemogloBind™ in Research on Human Abdominal Aortic Aneurysms
MONMOUTH JUNCTION, NJ, November 30, 2015 — Biotech Support Group reports on a journal article reports
which describe the simplicity and efficiency of their proteomic sample preparation technology for hemoglobin
depletion. The citation is:
Rubio-Navarro et al. Hemoglobin induces monocyte recruitment and CD163-macrophage polarization in abdominal aortic aneurysm. International Journal of Cardiology 201 (2015) 66–78.
Hemoglobin (Hb) is a strong oxidant catalyst that could lead to cell damage in the arterial wall. To restrain
these harmful effects, Hb is cleared by CD163, a scavenger receptor present on the surface of circulating
monocytes and tissue macrophages. A soluble form of CD163 (sCD163) has been also reported in plasma.
The role of Hb on monocyte recruitment and differentiation towards CD163 expressing macrophages in
human abdominal aortic aneurysms (AAA) was investigated. The authors conclude that the presence of Hb
in the adventitial AAA-wall promotes the migration and differentiation of activated circulating monocytes in
AAA patients, as such effects were partially suppressed when Hb was removed by the use of HemogloBind.
The article states “Conditioned medium from healthy aortas or AAA samples were treated with HemogloBind
reagent (Biotech Support Group LLC) according to the manufacturer’s protocol for hemoglobin depletion.
HemogloBind™ is a polyelectrolyte mixture designed to selectively bind hemoglobin from biological fluids.”.
“This report illustrates the essential features of HemogloBind™, that the selectivity profile is exquisite and that
after Hemoglobin removal – bio-activity, as exemplified by cellular response, remains.” states Swapan Roy,
Ph.D., President and Founder of Biotech Support Group.
About Biotech Support Group LLC
Biotech Support Group LLC is a leading provider of proteomic, metabolomic and genomic sample preparation
and enrichment products and services. It’s principal products include: AlbuVoid™ & AlbuSorb™ for albumin
depletion, Cleanascite™ for lipid adsorption and clarification, HemogloBind™ & HemoVoid™ for hemoglobin
removal, NuGel™ for functional & chemical proteomics, and ProCipitate™ for nucleic acid isolation. For more
information, go to http://www.biotechsupportgroup.com