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작성일 : 18-10-27
Purity 99%, ROCK Inhibitor Y-27632
 글쓴이 : 운영자
 

 

ROCK Inhibitor (Y-27632)

(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide Dihydrochloride

 

 

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A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinase (Ki=

140 nM for p160ROCK (ROCK-I). Also inhibitsROCK-II with almost equal potency. Inhibition is achieved by

competing with ATP for binding to the catalytic site. Exhibits 10- to 50-fold lower affinity for PKCεthan

p160ROCK. Does not affect the activity of p21-activated protein kinase(PAK) even at high concentrations

(~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation

and smooth muscle contractions (IC50 = 700 nM for phenylephrine-inducedcontractions in aortic strips).

Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hEScells without

affecting their pluripotency.

 

 

Details

Chemical Formula:

 

C14H21N3O·2HCl·H2O

CAS No.:

 

146986-50-7

Molecular weight:

 

338.3.

Purity:

99% by HPLC

Appearance:

 

white solid

Chemical name:

 

  

 

 

(1E,4S,4aR,5R,6aS,7S,9aR)-5-(Acetyloxy)-1-[[[3-(dimethylamino)propyl]

methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-7,11-dihydroxy-4-

(methoxymethyl)-4a,6a-dimethylcyclopenta[5,6]na-phtho[1,2-c]pyran-2,10(1H,4H)

-dione

Solubility:

 

water (100 mg/mL)

Storage:

Protect from light. Packaged under inert gas

 

 

References

 

 

Ordering information

   

Catalog No.

Product Name

Size

CD0141

ROCK Inhibitor (Y-27632)

1mg, 5mg, 10mg, 25mg, 50mg ,100mg, 250mg & 1g

 

 

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