SA(Streptavidin)-Dextramer, customized multimerization molecule
The SA-Dextramer combine the powerful Dextramer technology with a biotin-mediated click-on functionality.
SA-Dextramer is a research tool. The SA-Dextramer serves as a scaffold for attachment of any biotinylated
molecule. Resulting in a multimer which display a number of the biotinylated molecule, with(FITC, PE or
APC) or without a fluorescent marker.
Design a molecular vaccine, Drug, or Detection molecule
You simply add your biotinylated molecules e.g.
• Adjuvant molecules
• Nucleic acids (e.g. DNA/RNA/LNA/PNA)
• Lanthanide chelates, etc.
A large number of drugs, toxins, peptides and proteins have been published to be biologically functional with
a biotin moiety and many of these molecules are now commercially available. Most peptide and nucleic acid
suppliers offer biotin modified products. Biotin-labeled antibodies and other molecules are also commercially
available from many commercial suppliers. For molecules where a biotinylated version is not available
biotinylation reagents may be used, thus enabling biotinylation of almost any type of molecule or surface.
• Molecular vaccines
• Artificial antigen presentation
• Drug-targeting of autoreactive T cells
• Gene silencing of single T cells
• Delivery of macro molecules to T cells
• Lanthanide chelate labeling of T cells
• Detection of low affinity targets/receptors or cells
The SA-Dextramer is supplied at a concentration of 160 nM, with respect to SA-Dextramer. 2 µl of SA-
Dextramer corresponds to one test optimized for flow cytometry, when used to stain up to 106 HPBMC for
antigen specific T cells, in a sample volume of 50-100µl.
Four SA-Dextramer reagents are provided as unlabeled DX01-none, DX01-FITC, DX01-PE or DX01-APC
labeled Dextramer, each having a different valency for biotin-binding. Please refer in below.
Data sheet - Labeled (PDF)
Data sheet - None (PDF)