Antigen-specific B Cells, Explore B-cell Immunity
Understanding antigen-specific B-cell immunity represents a valuable approach to examine immune
responses to infection. Emerging technologies for B-cell immune profiling rely on the detection of B cells
based on B-cell receptor (BCR) recognition . DNA barcoded antigens in combination with the 10x
Genomics Feature Barcode technology were adopted to obtain simultaneous information on the BCR
sequences, antigen specificity, and genomic profiling at the single cell level .
With Klickmer™ and dCODE® Klickmer, you can now attach biotinylated pathogen-specific antigens to a
Dextramer backbone, generating a high-valence reagent to detect antigen-specific B cells based on BCR
recognition. The compatibility of dCODE Klickmer with the 10x Genomics Feature Barcode protocol for Single
Cell Immune Profiling also allows to obtain BCR sequencing and genomic profiling at single cell resolution.
Selected References for B-cell Analysis:
▣ 관련 페이지 ; Immudex